Under this circumstance, try running Fallout 4 in compatibility mode to fix the crashing error. It is terrible as it may damage your computer. Generally, Fallout 4 crashing error can be divided into 4 cases ( Fallout 4 keeps crashing, Fallout 4 crashing PC, Fallout 4 crash on launch, and Fallout 4 crash on Xbox One).
Fix 1: Configure the Graphics Option to Low.Minimum & Recommended System Requirements of Fallout 4.